hamacher(AT)bio(dot)tu-darmstadt(dot)de

Refereed Publications

T. Wulfmeyer, C. Polzer, G. Hiepler, K. Hamacher, R. Shoeman, D. Dunigan, J.L. Van Etten, M. Lolicato, A. Moroni, G. Thiel, T. Meckel. Structural organization of DNA in Chlorella viruses, PLoS One, accepted, 2011

K. Hamacher, Information Theoretical Dissection of the Holobiont - Host-Virus Interaction as an Example, Nova Acta Leopoldina, accepted, 2011

S. Weißgraeber, F. Hoffgaard, K. Hamacher, Structure-Based, Biophysical Annotation of Molecular Coevolution of Acetylcholinesterase, Proteins: Structure, Function, and Bioinformatics, 79(11):3144-3154, 2011.
Abstract & PDF

S. Bremm, T. von Landesberger, M. Hess, T. Schreck, P. Weil, K. Hamacher, Interactive Visual Comparison of Multiple Trees, IEEE Conference on Visual Analytics Science and Technology (VAST2011), accepted, 2011.

M. Waechter, K. Hamacher, F. Hoffgaard, S. Widmer, M. Goesele, Is Your Permutation Algorithm Unbiased for n≠2**m ? 9th Int. Conf. on Parallel Processing & Appl.Mathematics (PPAM2011), 2011.

E. Gehrmann, C. Glässer, Y. Jin, B. Sendhoff, B. Drossel, K. Hamacher, The robustness of glycolysis in yeast to internal and external noise. Phys. Rev. E 84:021913, 2011.
Abstract & PDF
This paper was discussed in a viewpoint article in Physics(APS) 4, 63 (2011)
(also selected for publication in the Virtual Journal of Biological Physics Research)

K. Hamacher, S. Katzenbeisser. Public Security: simulations need to replace conventional wisdom., Proceedings of the New Security Paradigms Workshop (NSPW11), ISBN 978-1-4503-1078-9, ACM, pp. 115-124, 2011.

K. Hamacher. Free Energy of Contact Formation in Proteins - Efficient Computation in the Elastic Network Approximation. Phys. Rev. E, 84:016703, 2011. (selected for publication in the Virtual Journal of Biological Physics Research)
Abstract & PDF

T. Strunk, K. Hamacher, F. Hoffgaard, H. Engelhardt, M.D. Zillig, K. Faist, W. Wenzel, F. Pfeifer. Structural Model of the Gas Vesicle Protein GvpA and Analysis of GvpA Mutants in vivo, Molecular Microbiology, 81(1):56-68, 2011
Abstract & PDF-Version

M. Gebhardt, F. Hoffgaard, K. Hamacher, S.M. Kast, A. Moroni, G. Thiel. Membrane anchoring and interaction between transmembrane domains is cruical for K+ channel function, J. Biol. Chem., 286(13):11299-11306, 2011
PubMed entry

B. Deiseroth, M. Franz, K. Hamacher, S. Jha, S. Katzenbeisser, H. Schröder. Towards Secure Bioinformatics Services, Financial Cryptography and Data Security (FC2011), 2010, (to appear in Springer Lecture Notes in Computer Sciences), accepted

D. Reker, S. Katzenbeisser, K. Hamacher. Computation of Mutual Information From Hidden Markov Models, Computational Biology and Chemistry, 34:328-333, 2010
Abstract & PDF-Version

B. Deiseroth, M. Franz, K. Hamacher, S. Jha, S. Katzenbeisser, H. Schröder. Secure Computation on Non-Integer Values, 2010 IEEE International Workshop on Information Forensics and Security (WIFS-2010), IEEE Press (ISBN 978-1-4244-9078-3) p. 1-6, 2010
IEEE-Xplore
IACR preprint

K. Hamacher. Efficient quantification of the importance of contacts for the dynamical stability of proteins, J. Comp. Chem., 32(5):810-815, 2011
Abstract & PDF-Version

S. Bremm, T. Schreck, P. Boba, S. Held, K. Hamacher. Computing and Visually Analyzing Mutual Information in Molecular Co-Evolution, BMC Bioinformatics, 11:330, 2010
    Abstract & PDF-Version

K. Hamacher. Efficient Perturbation Analysis of Elastic Network Models - Application to Acetylcholinesterase of T. californica, J. Comp. Phys., 229:7309-7316, 2010
Abstract & PDF-Version

K. Hamacher. Temperature dependence of fluctuations in HIV1-Protease, Eur. Biophys. J., 39:1051, 2010
Abstract & PDF-Version

F. Hoffgaard, P. Weil, K. Hamacher. BioPhysConnectoR: Connecting Sequence Information and Biophysical Models, BMC Bioinformatics, 11:199, 2010.
Abstract & PDF-Version

S. Pape, F. Hoffgaard, K. Hamacher. Distance-Dependent Classification of Amino Acids by Information Theory, Proteins: Structure, Function, and Bioinformatics, 78(10):2322-2328, 2010.
Abstract & Preprint

P. Boba, P. Weil, F. Hoffgaard, K. Hamacher. Intra- and Inter-Molecular Co-Evolution: The Case of of HIV1 Protease and Reverse Transcriptase, Proc. of BIOINFORMATICS 2010 (11% acceptance ratio, Best Paper Award), Springer Communications in Computer and Information Science 127:356-366, 2011
PDF-Version of Preproceedings-Paper,    Supplemental Material
PDF-Version

K. Hamacher. Protein Domain Phylogenies - Information Theory and Evolutionary Dynamics, Proc. of BIOINFORMATICS 2010 (11% acceptance ratio), p. 114-122, A. Fred, J. Filipe, H. Gamboa (eds.), ISBN 978-989-674-019-1
PDF-Version

P. Weil, F. Hoffgaard, K. Hamacher. Estimating Sufficient Statistics in Co-Evolutionary Analysis by Mutual Information, Computational Biology and Chemistry 33(6):440-444, 2009.
Abstract & PDF-Version

J. Ackermann, P. Baecher, T. Franzel, M. Goesele, K. Hamacher. Massively-Parallel Simulation of Biochemical Systems, Lecture Notes in Informatics, 154, 739-750, 2009, Proceedings of Massively Parallel Computational Biology on GPUs (BioGPU2009)
Entry at CUDA-Zone
Online-Version

K. Hamacher. Relating Sequence Evolution of HIV1-Protease to Its Underlying Molecular Mechanics , Gene, 422:30-36, 2008.
Abstract & PDF-Version
Erratum (PDF) to correct wrong table headings

K. Hamacher. Coarse-grained molecular models for high-throughput and multi-scale functional investigations, Chem.Cent.J., 2:S14, 2008.
Abstract & PDF-Version

K. Hamacher. Coarse-Grained Molecular Models for High-Throughput and Multi-Scale Functional Investigations, Proceedings of CBSB08 (From Computational Biophysics to Systems Biology), U.H.E. Hansmann, et al. (eds.), (ISBN 978-3-9810843-6-8), NIC Series Volume 40, 97-100, 2008.
PDF-Version

K. Hamacher. Adaptive Extremal Optimization by Detrended Fluctuation Analysis, J.Comp.Phys., 227(2):1500-1509, 2007.
Abstract & PDF-Version

K. Hamacher. Information Theoretical Measures to Analyze Trajectories in Rational Molecular Design, J.Comp.Chem., 28(16):2576-2580, 2007.
Abstract & PDF-Version

K. Hamacher. Energy landscape paving as a perfect optimization approach under detrended fluctuation analysis, Physica A 378(2):307-314, 2007.
Abstract & PDF-Version

K. Hamacher. Adaptation in Stochastic Tunneling Global Optimization of Complex Potential Energy Landscapes, Europhys.Lett. 74(6):944, 2006.
Abstract & PDF-Version

K. Hamacher, A. Hübsch, J.A. McCammon. A Minimal Model for Stabilization of Biomolecules by Hydrocarbon Cross-Linking, J.Chem.Phys. 124:164907, 2006. (selected for publication in the Virtual Journal of Biological Physics Research)
Abstract & PDF-Version

K. Hamacher, J.A. McCammon. Computing the amino acid specificity of fluctuations in biomolecular systems, J.Chem.Theo.Comp. 2:873, 2006.
Abstract & PDF-Version

K. Hamacher, J. Trylska, J.A. McCammon. Dependency Map of Proteins in the Small Ribosomal Subunit. PLoS Comput. Biol. 2(2): e10, 2006.
Online- & PDF-Version

K. Hamacher. On Stochastic Global Optimization of one-dimensional functions. Physica A 354:547-557, 2005.
Abstract & PDF-Version

C. Gros, K. Hamacher, W. Wenzel. Breakdown of the Luttinger sum-rule at the Mott-Hubbard transition in the one-dimensional t1-t2 Hubbard model. Europhys. Lett. 69(4):616, 2005.
Abstract & PDF

K. Hamacher, C. Gros, W. Wenzel. Interaction-induced collapse of a section of the Fermi sea in the zig-zag Hubbard ladder. Phys. Rev. Lett 88:217203, 2002. (selected for publication in the Virtual Journal of Nanoscale Science & Technology)
Reprint: PDF-Version

K. Hamacher, "Untersuchung quantenmechanischer Korrelationen mit der Dichtematrix-Renormierungsgruppe", PhD-Thesis, Dortmund University, 2001.
PDF-Version

K. Hamacher, J. Stolze, W. Wenzel. Disorder Induced Quantum Phase Transition in Random-Exchange Spin-1/2 Chains. Phys. Rev. Lett. 89:127202, 2002. (selected for publication in the Virtual Journal of Nanoscale Science & Technology)
Abstract & PDF

J. Sirker, A. Klümper, K. Hamacher. Groundstate properties of two-dimensional dimerized Heisenberg models. Phys. Rev. B, 65:134409, 2002.
Abstract & PDF

C. Gros, R. Valenti, J.V. Alvarez, K. Hamacher and W. Wenzel. Test of the frustrated spin-cluster model to describe the low-temperature physics of NaV2O5.    Phys. Rev. B (Rapid Comm.), 62(22):R14617-R14620, 2000.
Reprint: Postscript-Version,   PDF-Version

P. Stampfuß, K. Hamacher, and W. Wenzel. A massively parallel configuration-selecting multi-reference configuration interaction implementation. J. Mol.Struc.(THEOCHEM), 506:99-106, 2000.
Reprint: Postscript-Version,   PDF-Version

W. Wenzel and K. Hamacher. A Stochastic tunneling approach for global minimization. Phys. Rev. Lett., 82(15):3003-3007, 1999.
Abstract & PDF

W. Wenzel and K. Hamacher. Scaling Laws for Protein Folding. In D. Reguera, J.M.G. Vilar, and J.M. Rubi, editors, Statistical Mechanics of Biocomplexity, Springer Lecture Notes in Physics, New York, p. 62-71, 1999. Springer.

K. Hamacher and W. Wenzel. The Scaling Behaviour of Stochastic Minimization Algorithms in a Perfect Funnel Landscape. Phys. Rev. E, 59(1):938-941, 1999.
Abstract & PDF

K. Hamacher. "Optimierung Hochdimensionaler Funktionen im Hinblick auf die Strukturvorhersage von Proteinen" , 1998. Diploma Thesis. Available on request.

K. Hamacher and W. Wenzel. Scaling behaviour of Minimization Algorithms in a Simple Model of Protein Folding. In Proceedings of the HLRZ-Workshop ``Monte Carlo Approach to Biopolymers and Protein Folding'', Singapore, 1998. World Scientific.
Reprint: PostScript-Version,   PDF-Version

Invited Talks

"Computational modeling of intracellular networks beyond flux balance analysis", 1st Annual Meeting PlantEngine I: Current state and vision for the future, 11/18/2011, Murcia, Spain

Talk during Leopoldina-Symposium "Growth and Defence in Plants: Resource Allocation at Multiple Scales", 07/03-05/10, Freising, Germany

"Correlations Everywhere - from GPUs to Visual Analytics", 06/15/2011, Dept. of CS, University of Mainz

"Correlating Evolutionary Dynamics with the Biophysical Realm by Multi-Scale Simulations", 12/15/2010, Kolloquium of the Paul-Ehrlich-Institute des Bundesministeriums für Gesundheit (Federal Ministry of Health)

Talk during "Symposium on Viral Membrane Proteins, Structure, Dynamics and Modulation", Heidelberg University, 11/05-07/10, Germany

"Von der Sequenz zur Systemdynamik und zurück", Dept. of Mathematics, University Potsdam, Germany, 10/15/09

"Molecular Biophysics and Optimization", Groningen Optimization Seminar, Dept. of Mathematics, Rijksuniversiteit Groningen, 09/24/09
Abstract

"Annotating the molecular phenotype - how to understand HIV1-protease evolution towards drug resistance and a short story about the bacterial ribosome", Institute for Toxicology and Genetics, Research Center Karlsruhe, 06/02/09

"Annotation of the molecular phenotype - connecting information space with the biophysical realm", Theoretical Physics Colloquium, University of Cologne, 04/17/09

"Model Selection for Coevolution in Virology, Drug Resistance Developement, and Biophyiscs", Model Selection Day, joint workshop of the Max-Planck-Institute for molecular Genetics, Magdeburg University and the Max-Planck-Institute for Mathematics in the Natural Sciences, 04/06/09

"Reduced Molecular Models - a Computational Pipeline for Molecular Biophysics and Molecular Biology", CU New York, USA, 03/12/09

"Reduced Molecular Models - a Pipline for in silico Systemsbiology and Bioengineering", Merck KGaA, Darmstadt, Germany, 03/02/09

"Reduced Molecular Models : a Pipeline for in-silico Systemsbiology and Biomolecular Engineering", B-IT Center, Dept. of Computer Science, Bonn University, Germany, 12/23/08

"Reduzierte Molekularmodelle für das Biomolecular Design", FH Giessen-Friedberg, Germany, 12/17/08

"Connecting Physics & Information Theory: models for molecular phenotypes", Dept. of Physics, Technical University Dortmund, Germany, 09/01/08

"Connecting the Physical Realm to Biological Information Acquisition", Max-Planck-Institute for Physics of Complex Systems, Dresden, Germany, 08/28/08

"Global Optimization: a challenge in theoretical physics", Seminar in Optimization, Dept. of Mathematics, TU Darmstadt, 04/07/08
Abstract

"From the Genome to the Proteome: how phylogenetic relationships can be inferred from genomic data without the need for sequence alignment", Systematics 2008, 04/07-11/08, Göttingen, Germany

"Computational Biophysics at multiple scales" , Theoretical Physics Colloquium, TU Darmstadt, 01/07/08

"Reduzierte Molekulare Modelle in der Biochemie: Ein Brückenschlag zwischen Molekulardynamik und Bioinformatik?", 10. Steinheimer Gespräche des Fonds der chemischen Industrie, Hanau, Germany, 05/10/07-05/12/07

"Reduced Molecular Models - Bridging the Gap between Bioinformatics and Molecular Biophysics", Symposium "Perspectives in Computational Biophysics", Max-Planck-Institute for Biophysics, Frankfurt, Germany, 01/22/07

"A Computational Framework for Bioengineering - Global Optimization and Reduced Molecular Models", Aachen Institute for Advanced Studies in Computational Engineering Science, RWTH Aachen, Germany, 01/12/07

"Reduced Molecular Models - Bridging the Gap between Bioinformatics and Molecular Biophysics", Colloquium Biology Department, Technische Universität Darmstadt, 12/20/06

"Reduced Molecular Models - Increased Systems Knowledge", Gesellschaft für biotechnologische Forschung (GBF), Braunschweig, Germany, 06/01/06

"Assembly of the Small Ribosomal Subunit - Reduced Molecular Model Computations", Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany, 03/14/06

"Reduced Molecular Models", Soft Matter Physics Seminar, Düsseldorf University, Germany, 01/10/06

"Reduced Molecular Models - Going Beyond Bioinformatics", Symposium Biotechnological Center, Technical University Dresden, 12/20/05

"Global Optimization by Tunneling and its Application in Protein Structure Prediction", Biophysics Seminar, Ruhr-Universität Bochum, Germany, 10/10/05

"Amino-Acid specific fluctuations in biomolecular systems -- Application to HIV1-Protease", Interdisciplinary Center for Mathemical and Computational Modelling, Warsaw University, 05/11/05

"Accelerated technological change and the role of time horizons", Symposium on Modeling and Simulation: The future of life, Frankfurt University, 05/05/05

"Molekulare Biophysik der Signal Transduction in B.subtilis", Statistical Physics Group, Wuppertal University, 03/30/05

"Molecular Biophysics of Protein-Protein-Interactions in Signal Transduction", Seminar "Theoretical aspects of the physics of condensed matter", Dortmund University, 01/05/2005

"Molecular Biophysics of Protein-Protein-Interactions in Signal Transduction", Theoretisch Physikalisches Kolloquium, Saarbrücken University, 12/15/2004

"DMRG: von Spins bis zur ab-initio-Rechnung", Frankfurt University, 04/20/2004, slides (German, PDF)

"Correlation effects and DMRG", "Condensed Matter Seminar", Augsburg University, 11/18/2003, slides (English, PDF)

"Computation of correlation effects with the DMRG", "Graduiertenkolleg", Marburg University, 04/23/2001, slides (German, Postscript, Zip-file), slides (German, PDF, Zip-file)

Contributed Talks

"Monte-Carlo based Optimization in Computational Biophysics (and beyond)", CCP2010 - Conference on Computational Physics, Trondheim, Norway, 23-26/06/2010
Abstract (PDF)

"Coarse-Grained Parametrization of Protein Structure and Dynamics by Global Optimization", Annual Meeting of the Bunsen Society for Physical Chemistry, Bielefeld, Germany, 05/15/10

"Vom Kreationismus zum Kollektivismus - Fehlende Einsicht in die Leistung komplexer Systeme", 26C3, Berlin, 27-30.12.09
Video (1 of 6)

"Reduced Molecular Models for Functional Annotation of Molecular Phenotypes and Molecular Engineering", DFG/NSC Bilateral Symposium "Viral Membrane Proteins", Heidelberg, Germany, 12/13/08

"Introducing: BioPhysConnectoR", useR! 2008 conference, Dortmund, Germany, 08/13/08
Abstract

"Coarse-Grained Molecular Models for High-Throughput and Multi-Scale Functional Investigations", Workshop 'From Computational Biophysics to Systems Biology 2008', Jülich, Germany, 05/19-21/08

"From Quantum Chemistry to Go-Models in Biomolecular Design - functional peptides in the BCL2-protein-family in leukaemia", Workshop on Multiscale Methods for the Design of Biofunctional Molecules, University Essen-Duisburg, Germany, 04/02-04/08

"Coarse-Grained Molecular Models for High-Throughput and Mutli-Scale Functional Investigations", 3. German Conference on Chemoinformatics, 21. CIC-Workshop 2007, Goslar, Germany, 11/11-13/07

"Detrended Fluctuation Analysis in Stochastic Global Optimization", 71. Annual Meeting of the Deutschen Physikalischen Gesellschaft (DPG), Section Dynamics and Statistical Physics, Regensburg, Germany, 03/29/07

"Reduced Molecular Models in (Bio)molecular Design", 71. Annual Meeting of the Deutschen Physikalischen Gesellschaft (DPG), Section Biological Physics, Regensburg, Germany, 03/26/07

"Reduced Molecular Models - Increased Systems Knowledge", XX. Sitges Conference on Statistical Mechanics, Sitges, Spain, 06/05/06-06/09/06

"Amino-Acid specific fluctuations in biomolecular systems - Application to HIV1-Protease", Symposium Theoretical Chemistry (STC 2005), Innsbruck, Austria, 09/05/05-09/07/05

"Untersuchung quantenmechanischer Korrelationseffekte mit der Dichtematrix-Renormierungsgruppe", Disputation (German PhD-thesis defense), 12/20/2001, slides (Postscript, Zip-file), slides (PDF)

"Computation of correlation effects with the DMRG", Seminar "Theoretical aspects of the physics of condensed matter", Dortmund University, 01/31/2001, slides (German, Postscript, Zip-file), slides (German, PDF, Zip-file)

"Quantum Mechanics and Game Theory", joined seminar of the computer science and physics department, Dortmund University, 06/27/2000, slides (German, Postscript), slides (German, PDF)

"The Scaling Behaviour of Algorithms for Global Optimization in Protein Folding", Annual Meeting of the German Physical Society (DPG), Bayreuth, 03/11/1998, slides (German, Postscript), slides (German, PDF)

"Protein Folding", Seminar "Theoretical aspects of the physics of condensed matter", Dortmund University, Dec. 1997

Poster Contributions

M. Waechter, K. Hamacher, F. Hoffgaard, S. Widmer, M. Goesele, "Random Permutation on a GPU - Is Your Algorithm Unbiased for n ≠ 2**m ?", High-Performance Graphics (HPG 2011), Vancouver, BC, Canada

Poster C. Batram , N.G. Jones, K. Hamacher, M. Günzel, M. Engstler "VSG expression is monitored via a conserved stem-loop in the 3'UTR of VSG genes" at the Kinetoplastid Molecular Cell Biology Meeting 2009, Woodshole, MA, USA, 04/26/09-04/29/09

Poster "Novel approaches to combine information & physics in biomolecular systems" at the Conference "Physical and Chemical Foundations of Bioinformatics Methods", Germany, 06/18/07-06/22/07

Poster "A minimal Model for the Stabilization of Biomolecules by hydrocarbon crosslinkers" at the 367. WE-Heraeus-Seminar: Biomolecular Simulation: From Physical Principles to Biological Function, Bad Honnef, Germany 05/22/06-05/24/06

Poster "Computing amino-acid specific fluctuations in biomolecular systems - Application to HIV1-Protease" at the First European Conference on Chemistry for the Life Sciences, Rimini, Italy, Oct. 05

Poster "Computing amino-acid specific fluctuations in biomolecular systems - Application to HIV1-Protease" at the American Conference on Theoretical Chemistry (ACTC 2005), Los Angeles 07/16/05-07/21/05

Poster "Protein-Protein-Interactions in Signal Transduction" at 91. Bunsen-Kolloquium, Göttingen University, 04/05/05-04/06/05

Poster "Two Aspects of Correlations in Spin-Chains: Breakdown of Universality in Random-Exchange S=1/2 XXZ Chains and Results for dimerized 2D-Heisenberg-Systems" at the Symposium "New Trends in DMRG", Forschungszentrum Jülich, Germany, 07/23/2001
PDF-Version (English)

Poster "Correlations in Random-Exchange S=1/2 XXZ-Chains - Breakdown of Universality" at the conference "Korrelationstage 2001" of the Max-Planck-Institute for complex systems, Dresden, Germany, 02/14-17/2001
Postscript-Version (English), PDF-Version (English)

Talk R.Bundschuh, K.Hamacher, T.Hwa, "RNA secondary structures and phase transitions" , March Meeting of the American Physical Society 1999, Atlanta, GA, USA, 3/21/99-3/26/99
Postscript-Version (English), PDF-Version (English)

Poster "Scaling Behaviour of Minimization Algorithms for a Simple Model of Protein Folding" at the HLRZ-Workshop "Monte Carlo Approach to Biopolymers and Protein Folding", Jülich, 1997
Postscript-Version (English), PDF-Version (English)

Miscellaneous Papers

K. Hamacher. Leistungssschutzrecht: Fragwürdiger Schutz vor der Medienevolution Carta.Info, 2010.
Online-Version

K. Hamacher. Vom Kreationismus zum Kollektivismus - Fehlende Einsicht in die Leistung komplexer Systeme Proc. of 26C3, 2009, 243-247.
(ISBN 978-3-934636-08-8-0)
Paper (PDF)

K.Hamacher, "Probability, Statistics, Science?", ZiF:Mitteilungen, Bielefeld University, 2009(1)52

K.Hamacher, "Accelerated technological change and the role of time horizons", Proceedings of the Symposium on Modeling and Simulation: The Future of Life and the Future of our Civilization, 2006, Springer Series on Biomedicine, pp. 205-215, ISBN 978-1-4020-4968-2
Paper (PDF) at Springer
Paper (PDF) at Z25

K.Hamacher, "Nutzung der Compute-Server in der Computational Physics", ComputerPostille, Hochschulrechenzentrum, Universität Dortmund, 2000 (German)
Postscript-Version,   PDF-Version

K. Hamacher. MINILIB - Documentation for the Minimzation-Objects. Technical report, Theoretical Physics, Dortmund University, 1997.

Please comply with the copyrights of the publications.